Questions and Answers
Pls, need a good Explaination to this question. Thanks.
Neither are good when smoked because of the damage the particulates cause to the lung tissues. Because nicotine is addictive and tobacco is legal the lung damage and carcinogenic properties have been well documented.
The CDC statistics provide
"More deaths are caused each year by tobacco use than by all deaths from human immunodeficiency virus (HIV), illegal drug use, alcohol use, motor vehicle injuries, suicides, and murders combined"
Marijuana smoking damage has less research
However there are medical uses for nicotine just as there are for the cannabinoids so both have beneficial properties when delivered in a safe method at functional dosages given the patient's problem.
There is some evidence that nicotine might benefit some people as long as it isn't delivered by smoking. Low doses of nicotine can have dramatic effects in controlling the symptoms of Tourette's syndrome. It can also limit some of the problems in schizophrenics. Nicotine skin patches are even used for Alzheimer's patients and for those with ADD.
Cannabinoids, include cannabinol, cannabidiol, cannabinolidic acids, cannabigerol, cannabichromene, and several isomers of tetrahydrocannabinol (THC). The psychoactive isomer is Delta 9 Tetrahydrocannabinol .
Cannabidiol or CBD is a non-psychoactive cannabinoid. It has been shown to be effective as analgesic and anti-inflammatory with uses as an anti-asthmatic, and anti-rheumatic drug.
Tetrahydrocannabinol or THC is the only psychoactive component, the cannabinoid that gets people high. THC is an appetite stimulant, and an antiemetic so it is used in anorexic patients or in others whose conditions caused weight loss as well as in controlling moderate nausea and vomiting associated with cancer chemotherapy.
Medical research in cannabinoids
Both are drugs that can be abused but both are drugs with potential benefits.
Are the effects simuler or different. Is smoking it much worse that swollowing a THC pill ?
Doc, im sorry you find me mentaly ill. I also have cancer and get very nausated when taking my other meds. If you were a real doc you would consider this. And only a mentally ill person would make fun of a sick person. I am legal with the drugs i do take
Goatmilk, i thanko you for politly giving me your opinion, i dont mind that.
Marinol1 (dronabinol) is the only US FDA-approved synthetic cannabinoid. It is often marketed as a legal pharmaceutical alternative to natural cannabis.
Marinol is manufactured as a gelatin capsule containing synthetic delta-9-tetrahydrocannabinol (THC) in sesame oil. It is taken orally and is available in 2.5mg, 5mg and/or 10mg dosages. Marinol may be prescribed for the treatment of cachexia (weight loss) in patients with AIDS and for the treatment of nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments.
Despite FDA approval2, Marinol typically provides only limited relief to select patients, particularly when compared to natural cannabis and its cannabinoids. Marinol should remain a legal option for patients and physicians; however, federal and state laws should be amended to allow for those patients who are unresponsive to synthetic THC the ability to use natural cannabis and its cannabinoids as a medical therapy without fear of arrest and/or criminal prosecution. By prohibiting the possession and use of natural cannabis and its cannabinoids, patients are unnecessarily restricted to use a synthetic substitute that lacks much of the therapeutic efficacy of natural cannabis.
I. Marinol Lacks Several of the Therapeutic Compounds Available in Natural Cannabis
Chemical compounds in cannabis, known as cannabinoids, are responsible for its numerous therapeutic benefits. Scientists have identified 66 naturally occurring cannabinoids.3
The active ingredient in Marinol, synthetic delta-9-tetrahyrdocannabinol (THC), is an analogue of one such compound, THC. However, several other cannabinoids available in cannabis — in addition to naturally occurring terpenoids (oils) and flavonoids (phenols) — have also been clinically demonstrated to possess therapeutic utility. Many patients favor natural cannabis to Marinol because it includes these other therapeutically active cannabinoids.
For example, cannabidol (CBD) is a non-psychoactive cannabinoid that has been clinically demonstrated to have analgesic, antispasmodic, anxiolytic, antipsychotic, antinausea, and anti-rheumatoid arthritic properties.4
Animal and human studies have shown CBD to possess anti-convulsant properties, particularly in the treatment of epilepsy.5 Natural extracts of CBD, when administered in combination with THC, significantly reduce pain, spasticity and other symptoms in multiple sclerosis (MS) patients unresponsive to standard treatment medications.6
Clinical studies also demonstrate CBD to be neuroprotective against glutamate neurotoxicity7 (i.e. Stroke), cerebral infarction8 (localized cell death in the brain), and ethanol-induced neurotoxicity,9 with CBD being more protective against glutamate neurotoxicity than either ascorbate (vitamin C) or alpha-tocopherol (vitamin E).10 Clinical trials have also shown CBD to possess anti-tumoral properties,11 inhibiting the growth of glioma (brain tumor) cells in a dose dependent manner and selectively inducing apoptosis (programmed cell death) in malignant cells.12
Additional cannabinoids possessing clinically demonstrated therapeutic properties include: cannabinol (anticonvulsant13 and anti-inflammatory14 activity); cannabichromine (anti-inflammatory15 and antidepressant16 activity); and cannabigerol (anti-tumoral17 and analgesic18 activity). Natural cannabis' essential oil components (terpenoids) exhibit anti-inflammatory properties19 and its flavonoids possess antioxidant activity.20 Emerging clinical evidence indicates that cannabinoids may slow disease progression21 in certain autoimmune and neurologic diseases, including multiple sclerosis22 (MS), Amyotrophic Lateral Sclerosis23 (Lou Gehrig's disease) and Huntington's Disease.24
Clinical data indicate that the synergism of these compounds is likely more efficacious25 than the administration of synthetic THC alone.26 For example, McPartland and Russo write: "Good evidence shows that secondary compounds in cannabis may enhance beneficial effects of THC. Other cannabinoid and non-cannabinoid compounds in herbal cannabis … May reduce THC-induced anxiety, cholinergic deficits, and immunosuppression. Cannabis terpenoids and flavonoids may also increase cerebral blood flow, enhance cortical activity, kill respiratory pathogens, and provide anti-inflammatory activity."27 In an in vitro model of epilepsy, natural cannabis extracts performed better than THC alone.28 In human trials, patients suffering from multiple sclerosis experienced greater symptomatic relief from sublingual natural cannabis extracts than from the administration of oral THC.29 In 2005, Health Canada approved the oral spray Sativex30 — which contains precise ratios of the natural cannabinoid extracts THC and CBD, among other compounds — for prescription use for MS-related symptoms.31
II. Marinol is More Psychoactive Than Natural Cannabis
Patients prescribed Marinol frequently report that its psychoactive effects are far greater than those of natural cannabis. Marinol's adverse effects include: feeling "high," drowsiness, dizziness, confusion, anxiety, changes in mood, muddled thinking, perceptual difficulties, coordination impairment, irritability, and depression.32 These psychoactive effects may last four to six hours.33 About one-third of patients prescribed Marinol report experiencing one or some of these adverse effects.34
Marinol’s oral route of administration is responsible, in part, for its heightened psychoactivity compared to inhaled cannabis. Once swallowed, Marinol passes from the stomach to the small intestine before being absorbed into the bloodstream. Following absorption, Marinol passes through the liver where a significant proportion of the drug is metabolized into other chemicals.35 One of these chemicals, 11-hydroxy-THC, may be four to five times more potent than natural THC,36 and is produced in greater quantities.37 Thus, patients administered Marinol experience the psychoactive effects of both THC and 11-hydroxy-THC, greatly increasing the likelihood that they will suffer from an adverse psychological reaction. By comparison, only minute quantities of 11-hydroxy-THC are produced when cannabis is inhaled.38 Moreover, Marinol lacks the compound cannabidiol, which possesses anxiolytic activity and likely modifies and/or diminishes much of THC's psychoactivity in natural cannabis.39.
They smoke or eat a weed Cookie? I'm not saying I'm going to do it but I've always wondered. Do they get the same effect? Is it dangerous? Like would they flip out?
'Smoking-medical marijuana. It provides immediate effect and the patient has the ability to control the dosage. Problem with smoking is the ingredients in the smoke can result in respiratory problems, such as coughing, excessive sputum production, wheezing, and also in lung damage..many researchers believe that it contains carcinogens, toxins, this increases the risk of cancer & respiratory diseases… Researchers recommend people to look for some other method to consume medical marijuana… Long-term smoking of medical marijuana can hasten the weakening of lung function. For many patients smoking medical marijuana to increase quality of life is often worth the long-term risks.
Eating Medical Marijuana- patients who experience lung/throat problems due to smoking of medical marijuana, there are medical marijuana edibles available in the form of cookies, teas, lollipops and brownies. It is believed eating medical marijuana is a better way to ingest the THC, the active ingredient in cannabis. Not without risks. When a patient eats medical marijuana, the active ingredient does not get absorbed into the blood as quickly as it would have if the patient had smoked the cannabis. As a result, the effects of the marijuana take long to manifest and this increases the chances of overdose. Also, patients suffering from nausea cannot stomach eat.http://blog.4thstreetmedical.com/medical-marijuana-is-it-better-to-eat-or-smoke-it/#sthash.33TKlHPH.dpuf
Http://www.psychologytoday.com/blog/prom… 'primary symptoms of autism & why marijuana doesn't help.3 significant symptoms an autistic child suffers from, these are problems in socially relating to others, qualitative impairments in communicating & restrictive repetitive, stereotyped patterns of behavior. Marijuana does not improve any of these symptoms. According to the National Institute on Drug Abuse..heavy marijuana use, (smoking for 27 consecutive days or more,) leads to a decline in a person's ability to learn, retain information & function successfully in society. Being able to socially relate to others in diverse settings is learned behavior, so for a child who already struggles with this skill, marijuana decreases the likelihood that any progress will be made on the issue…1978 research study conducted on "marijuana and the perception of effect."The results of this study strongly suggested that consumption of marijuana significantly reduced an individual's ability to perceive emotions in others. Needless to say the ability for one person to perceive emotions in another involves empathy on the perceiver's part and for empathy to be present; communication also has to be present. Yet another reason why giving marijuana to an autistic child is a poor medical decision, as the likelihood of a child's being able to improve upon poor communication skills is significantly reduced. Third symptom of autism in children which has to do with restrictive, repetitive & stereotyped patterns of behaviors, all have to do with the child or adolescent developing an awareness on how certain socially unacceptable behaviors can put others off, and can cause a child to experience excessive episodes of rejection. Again being able to read social cues, all comes down to being empathetic.
Http://www.rcpsych.ac.uk/healthadvice/pr… 'How does it work & what is the chemical make-up of cannabis? There are about 400 chemical compounds in an average cannabis plant. The 4 main compounds are called delta-9-tetrahydrocannabinol (delta-9-THC), cannabidiol, delta-8-tetrahydrocannabinol and cannabinol. Apart from cannabidiol (CBD), these compounds are psychoactive, the strongest one being delta-9-tetrahydrocannabinol. The stronger varieties of the plant contain little cannabidiol (CBD), whilst the delta-9-THC content is a lot higher.
When cannabis is smoked, its compounds rapidly enter the bloodstream and are transported directly to the brain and other parts of the body. The feeling of being ‘stoned’ or ‘high’ is caused mainly by the delta-9-THC binding to cannabinoid receptors in the brain. A receptor is a site on a brain cell where certain substances can stick or “bind” for a while. If this happens, it has an effect on the cell and the nerve impulses it produces. Curiously, there are also cannabis-like substances produced naturally by the brain itself – these are called endocannabinoids. Most of these receptors are found in the parts of the brain that influence pleasure, memory, thought, concentration, sensory and time perception. Cannabis compounds can also affect the eyes, the ears, the skin and the stomach.